960113-85-3

BR351 is a brain penetrant MMP inhibitor for MMP2, MMP8, MMP9 and MMP13, respectively.

BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively[1].

MMP-9: 11 nM (IC₅₀); MMP-2: 4 nM (IC₅₀); MMP-8: 2 nM (IC₅₀); MMP13: 50 nM (IC₅₀)

[1] Wagner S, et al. Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J DOI:10.1021/jm0708533