959766-47-3

CH5015765 is a novel, potent, and selective HSP90 inhibitor. CH5015765 showed high affinity for Hsp90 and antitumor activity in human cancer xenograft mouse models.

CH5015765 is an orally available Hsp90 inhibitor bound to the N-terminal ATP binding site. CH5015765 plays an important role in cancer research[1].

HSP90

[1] Atsushi Suda, et al. Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1136-41. DOI:10.1016/j.bmcl.2011.11.100