959746-77-1

A-836339 is a synthetic cannabinoid (CB) which has a higher affinity for the peripheral CB₂ receptor (K_i = 0.64 nM) over the central CB₁ receptor (K_i = 270 nM). It displays analgesic, anti-inflammatory, and anti-hyperalgesic effects in mice. At higher doses, A-836339 also decreases spontaneous locomotor activities, consistent with CB₁ activation. This product is intended for forensic and research applications.

A-836339, is a cannabinoid CB2 receptor-selective agonist; exhibits high potencies at CB(2) and selectivity over CB(1) receptors. Synthetic Cannabinoids.

[1] BETTY B YAO. Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging.[J]. Journal of Pharmacology and Experimental Therapeutics, 2009, 328 1: 141-151. DOI: 10.1124/jpet.108.145011
[2] S. MCGARAUGHTY. A CB2 receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: Contributions of spinal and peripheral CB2 receptors[J]. Neuroscience, 2009, 158 4: Pages 1652-1661. DOI: 10.1016/j.neuroscience.2008.11.015