Description
TP0438836 is a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor for the treatment of type 2 diabetes. TP0438836 showed IC50 values 28nM and 7 nM for hSGLT1 and hSGLT2 resepctively.
Uses
TP0438836 (compound 30b) is a SGLT1 inhibitor, with IC50 values ??of 28 nM and 7 nM for hSGLT1 and hSGLT2, respectively. TP0438836 can be used in diabetes research[1].
IC 50
hSGLT1: 28 nM (IC50); hSGLT2: 7 nM (IC50)
References
[1] Kuroda S, et al. Discovery of a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor (TP0438836) for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3534-3539. DOI:
10.1016/j.bmcl.2018.09.035
