Potential Exposure
Pyriproxyfen is an unclassified insect
growth regulator, insecticide, veterinary medicine found in
a number of household products as sprays, powders, baits,
mists and shampoos for the control of fleas, ticks, mites,
and flying insects on pets, in the air, and in carpets and
rugs. It’s a l larvicidal agent that mimics juvenile insect
hormone.
First aid
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions) if
breathing has stopped, and CPR if heart action has stopped.
Transfer promptly to a medical facility. When this chemical
has been swallowed, get medical attention. Give large
quantities of water and induce vomiting. Do not make an
unconscious person vomit.
Shipping
UN3077 Environmentally hazardous substances,
solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz-
ardous material, Technical Name Required.
Incompatibilities
This material is combustible. Dust may
form an explosive mixture in air. Incompatible with oxidi-
zers (chlorates, nitrates, peroxides, permanganates, perchlo-
rates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials,
strong bases, strong acids, oxoacids, epoxides.
Description
Pyriproxyfen is a pyridine compound and, in common
with fenoxycarb, is a juvenile hormone mimic whose
structure is unrelated to natural juvenile hormone. It
is an insect growth regulator. Fleas absorb pyriproxyfen
either by direct contact or by ingesting blood from a
treated animal.
Waste Disposal
It is the responsibility of
chemical waste generators to determine the toxicity and
physical properties and of a discarded chemical and to
properly identify its classification and certification as a hazardous waste and to determine the disposal
method. United States Environmental Protection Agency
guidelines for the classification determination are listed
in 40 CFR Parts 261.3. Additionally, waste generators
must consult and follow all regional, national, state and
local hazardous waste laws to ensure complete and
accurate classification and disposal methods. Follow
recommendations for the disposal of pesticides and
pesticide containers. Containers must be disposed
of properly by following package label directions or by
contacting your local or federal environmental control
agency, or by contacting your regional EPA office.
Definition
ChEBI: An aromatic ether that consists of propylene glycol having a 2-pyridyl group at the O-1 position and a 4-phenoxyphenyl group at the O-3 position.
Agricultural Uses
Insect growth regulator, Insecticide, Veterinary medicine: Pyriproxyfen is found in a number of household products as sprays, powders, baits, mists and shampoos for the control of fleas, ticks, mites and flying insects on pets, in the air, and in carpets and rugs. It’s a larvicidal agent that mimics juvenile insect hormone.
Trade name
ARCHER®; DALAR®; DISTANCE®; ESTEEM®; NYLAR®; S-9318®; S 31183®; SUMILARV® Pyriproxyfen
Metabolic pathway
Pyriproxyfen is not persistent in soils and sediments and is rapidly
metabolised by a variety of organisms. In rats and mice, the major
metabolic pathways were hydroxylation of the aromatic ring, hydroxylation
at the 5-position of the pyridyl ring, loss of the aromatic ring,
cleavage of ether linkages and conjugation of the resultant phenols with
glucuronic or sulfuric acid. The general pathways in soils, sediments
and a variety of organisms involve fission of ether linkages and hydroxylation
of the phenoxyphenol group.
Degradation
[14C]Pyriproxyfen was dissolved in distilled water or sterile river water
at a concentration of 0.2 mg kg-1 and exposed to natural sunlight from
November to December at 40°N latitude. The DT50 values were 17.5
and 21 days in distilled water and sterile river water respectively. Photodegradation
involved cleavage at the three ether linkages and the major
products were carbon dioxide (11-29% of the applied radioactivity) and a
product formed by loss of the phenoxyphenyl group (9) (16-30%). When
[14C]pyriproxyfen was exposed to sunlight for 8 weeks on sandy loam
and silty loam soils, the DT50 values were 11 and 13 weeks respectively.
Photodegradation involved cleavage at the three ether linkages to give
products 4,6 and 10 but the major product was carbon dioxide, representing
9.5-13% of the applied radioactivity. Bound radioactivity accounted
for 11-26% of the applied radioactivity at week 8 (Miyamoto et al., 1993).
Degradation products are shown in Scheme 1.
