Chemical Properties
Crystalline Solid
Uses
Anesthetic (intravenous).
Controlled substance (depressant).
Uses
Controlled substance (depressant). Anesthetic (intravenous).
Biological Activity
Non-competitive NMDA receptor antagonist and sigma receptor agonist. Psychostimulant; induces rotational behavior, head-weaving and cognitive dysfunction in rats.
Brand name
Sernylan (Parke-Davis).
Biochem/physiol Actions
σ opioid receptor agonist and psychostimulant; inhibits NMDA glutamate receptor activation by binding to an allosteric site within the ion channel.
Safety Profile
Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Human systemic effects by ingestion and intravenousroutes: distorted perceptions, euphoria, excitement,hallucinations, and paresthesia. An experimental teratogen.Other experime