953798-95-3

Name	3-Quinolinecarboxamide, 4-[(2,4-difluorophenyl)amino]-7-ethoxy-6-(4-methyl-1-piperazinyl)-
CAS	953798-95-3
Molecular Formula	C23H25F2N5O2
Molecular Weight	441.47
MOL File	953798-95-3.mol

Synonyms

AZ683 3-Quinolinecarboxamide, 4-[(2,4-difluorophenyl)amino]-7-ethoxy-6-(4-methyl-1-piperazinyl)-

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Chemical Properties

form	Solid
color	White to light yellow

Hazard Information

Uses

AZ683 is a potent and selective 3-amido-4-anilinoquinoline CSF1R inhibitor. AZ683 has high affinity for CSF1R (Ki=8 nM; IC50=6 nM). AZ683 has good oral bioavailability. [11C]AZ683 can be used as a positron emission tomography (PET) radiotracer for colony stimulating factor 1 receptor (CSF1R)[1][2].

References

[1] Tanzey SS, et al. Synthesis and Initial In Vivo Evaluation of [11C]AZ683-A Novel PET Radiotracer for Colony Stimulating Factor 1 Receptor (CSF1R). Pharmaceuticals (Basel). 2018 Dec 13;11(4):136. DOI:10.3390/ph11040136
[2] Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6. DOI:10.1016/j.bmcl.2013.06.031

Supplier

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Telephone 15317229551

Websitehttps://www.ureiko.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Guangzhou New Century Technology Co., Ltd.

Telephone020-13113998854 13113998854

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList32626/0_EN.htm

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