Potential Exposure
Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill
birds. It is marketed as pelleted bait for control of bird
populations.
First aid
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
Shipping
UN2239 Chlorotoluidines, solid, Hazard Class:
6.1; Labels: 6.1-Poisonous materials. UN3429
Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1-
Poisonous materials
Incompatibilities
Incompatible with oxidizers, strong
acids; chloroformates, and acid anhydrides, isocyanates,
aldehydes forming fire and explosive hazards.
Chemical Properties
clear yellow to light brown liquid after melting
Chemical Properties
The chloromethylanilines are colorless or
white crystalline solids or liquids, some have a mild
fishy odor.
Uses
5-Chloro-2-toluidine, is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds including inhibitors. It is a carcinogenic monocyclic amine. The compound is used in synthesizing dyes.
Definition
ChEBI: 5-Chloro-ortho-toluidine is a member of monochlorobenzenes.
Carcinogenicity
A bioassay for the possible carcinogenicity of 5-chloro-otoluidine
was conducted using Fischer 344 rats and B6C3F1
mice. Groups of 50 male and 50 female rats and mice were
given 5-chloro-o-toluidine in the diet at 2500 or 5000 ppm for
rats and 2000 or 4000 ppm for mice. The compound was
administered for 78 weeks to both rats and mice, followed by
an observation period of up to 26 weeks for rats and 13 weeks
for mice. Under the conditions of this bioassay, 5-chloro-otoluidine
was carcinogenic to the mice, inducing hemangiosarcomas
and hepatocellular carcinomas in both males and
females. There was no conclusive evidence of the carcinogenicity
of the compound in the rats.
