General Description
A colorless to amber liquid with an unpleasant, penetrating odor. Density 1.265 g/cm3. Sinks in water and slowly dissolves. Freezing point 7°C (46°F). Boiling point 175°C (347°F).
Reactivity Profile
2-CHLOROPHENOL(95-57-8) is a weak acid. Neutralizes bases in exothermic reactions. Incompatible with oxidizing agents. Incompatible with acid chlorides and acid anhydrides. Forms ethers, esters and salts with metals and amines .
Air & Water Reactions
Very soluble in water
Hazard
Toxic by skin absorption, inhalation, or
ingestion. Strong irritant to tissue.
Health Hazard
Poisonous; may be fatal if inhaled, swallowed or absorbed through skin. Irritating to skin and eyes; direct contact may cause burns. Rats receiving lethal doses via oral, subcutaneous or intraperitoneal routes displayed similar symptoms: restlessness, increased breathing rate and motor weakness followed by tremors, chronic convulsions, dyspnea, coma and death.
Potential Exposure
Monochlorophenols are used in the
manufacture of fungicides, slimicides, bactericides, pesticides, herbicides, disinfectants, wood and glue preservatives; in the production of phenolic resins; in the extraction
of certain minerals from coal; as a denaturant for ethanol;
as an antiseptic; as a disinfectant, and others.
First aid
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts
the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from
exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has
stopped and CPR if heart action has stopped. Transfer
promptly to a medical facility. When this chemical has
been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
Shipping
UN 2020 (solid); UN2021 (liquid) Chlorophenols, solid and liquid, Hazard Class: 6.1; Labels:
6.1-Poisonous materials.
Incompatibilities
May form explosive mixture with air.
Contact with oxidizing agents can cause fire and explosion
hazard. Heat produces hydrogen chloride and chlorine.
Corrosive to aluminum, copper and other chemically active
metals.
Description
All have a characteristic odor. Odor threshold =1.24 ppm (pure). Molecular weight (all isomers) =128.56.m-isomer
Colorless (in pure state) to pink or amber (technical grade,due to impurities) crystalline solid or liquid. Boilingpoint =214℃; Freezing/Melting point =32.8℃; Specificgravity (H2O:1) =1.245; Vapor pressure =5 mmHg at70℃; Flash point =112℃. Solubility in water=2.6-2.8.5% at 20℃. Hazard Identification (based onNFPA 704 M Rating System): Health 2, Flammability 0,Reactivity 0.
o-isomerWhite crystalline (needle-like) solid. Boilingpoint =175.6℃; Freezing/Melting point =9.3-9.8℃;Specific gravity (H2O:1) =1.3; Vapor pressure, Pa at20℃ =230; Relative vapor density (air =1) =4.4; Flashpoint =64℃ (cc). Hazard Identification (based on NFPA704 M Rating System): Health 3, Flammability 2,Reactivity 0. Solubility in water =2.7% at 20℃.p-isomer
White to straw-colored, needle-like crystalline solid.Boiling point =218℃; Freezing/Melting point =43℃;Vapor pressure =10 mmHg at 20℃; Vapor density (air=1) =4.44; Flash point = 121℃ (cc). HazardIdentification (based on NFPA 704 M Rating System):Health 3, Flammability 1, Reactivity 0. Solubility inwater =2.71% at 20℃.
Chemical Properties
2-Chlorophenol is a colourless to light brown liquid, All isomers have a characteristic odor. It is used to make dyes and other chemicals, and as a disinfectant, bactericide, and germicide.
Waste Disposal
Incinerate in admixture with
flammable solvent in furnace equipped with afterburner
and scrubber.
Physical properties
Pale amber liquid with a slight phenolic, floral, or musty-type odor. At 40 °C, the average and
lowest odor concentrations detected were 0.36 and 0.088 μg/L, respectively. At 25 °C, the average
taste threshold concentration and the lowest concentration at which a taste was detected were 0.97
and 0.94 μg/L, respectively (Young et al., 1996).
Application
2-chlorophenol is used in medicine, pesticides, dyes and organic synthesis. It is an intermediate in the production of the pesticides Profenofos and Isoprocarb. It is also utilized in the manufacture of dye-stulfs and in the process for extracting sulphur and nitrogen compounds from coal. 2-chlorophenol functions as a reagent in the preparation of chlorophenyl phosphorodichloridothioate as potential synthon for oligonucleotide phosphorothioates.
Definition
ChEBI: 2-chlorophenol is a monochlorophenol and a 2-halophenol.
Preparation
0.5 mole of tert-butyl hypochlorite is dropped, with stirring, into a solution or suspension of the 0.5 mole of phenol in 150-300 ml of carbon tetrachloride, the temperature being allowed to rise to the boiling point of the solvent. The mixture is then boiled under reflux for a further 2 hours, the carbon tetrachloride and the tert-butyl alcohol are distilled off, and the residue is fractionated collecting fraction boiling at 174.9 °C.
storage
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with chlorophenols you should be trained on its proper handling andstorage. Before entering confined space where chlorophenols may be present, check to make sure that an explosiveconcentration does not exist. Store in tightly closed containers in a cool, well-ventilated area. Metal containers involving the transfer of this chemical should be grounded andbonded. Where possible, automatically pump liquid fromdrums or other storage containers to process containers.Drums must be equipped with self-closing valves, pressurevacuum bungs, and flame arresters. Use only nonsparkingtools and equipment, especially when opening and closingcontainers of this chemical. Sources of ignition, such assmoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could createa potential fire or explosion hazard. A regulated, markedarea should be established where this chemical is handled,used, or stored in compliance with OSHA Standard1910.1045.
Purification Methods
Pass 2-chlorophenol at least twice through a gas chromatography column. It has also been purified by fractional distillation. [Beilstein 6 IV 782.]
Toxics Screening Level
The current initial threshold screening level (ITSL) for 2-chlorophenol is 18 μg/m3 based on a 24 hour averaging time.
