948842-66-8

Name	Bms751324
CAS	948842-66-8
Molecular Formula	C32H35N6O10P
Molecular Weight	694.63
MOL File	948842-66-8.mol

Synonyms

Bms751324 BMS-751324 (BMS751324) [[4-[5-(cyclopropylcarbamoyl)-2-methylanilino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carbonyl]-propylcarbamoyl]oxymethyl 2-(4-phosphonooxyphenyl)acetate Benzeneacetic acid, 4-(phosphonooxy)-, 1-[[[[[[4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbonyl]propylamino]carbonyl]oxy]methyl] ester

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Chemical Properties

density	1.50±0.1 g/cm3(Predicted)
pka	1.21±0.30(Predicted)

Hazard Information

Uses

BMS-751324 is a p38α MAPK inhibitor. BMS-751324 equips a precursor of carbamyl-methyl linkage, containing esters and phosphate functional groups derived from hydroxyphenylacetic acid (HPA). BMS-751324 effectively inhibits foot swelling and LPS-induced TNFα production in an arthritic rat model[1].

in vivo

BMS-751324 (1 mg/kg, 3mg/kg; p.o.; twice daily for 1 week) inhibits paw swelling in rat adjuvant arthritis model, as well as (1 mg/kg, 3mg/kg; p.o.; single dose) inhibiting LPS-induced TNFα production^[1].
BMS-751324 (1 mg/kg-100 mg/kg for rat, 10 or 30 mg/kg for monkey with 5 mL/kg of methocel suspension; p.o.; single dose) exhibits a bio-conversion in animals^[1].

References

[1] Liu C, et al. Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo [1, 2-f][1, 2, 4] triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases[J]. Journal of medicinal chemistry, 2010, 53(18): 6629-6639.

Supplier

Amadis Chemical Company Limited

Telephone571-89925085

Websitehttp://www.amadischem.com

Beijing Biocreative Technology Co., Ltd.

Telephone 15522676233

Websitehttp://www.bestbaiao.com/

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85560043 15850508050

Websitehttp://www.synzest.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Biosynth Biological Technology (Suzhou) Co Ltd

Telephone 51288865780

Websitehttp://www.biosynth.com

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