942518-19-6

L-Homopropargyl glycine is a reactive methionine analog that contains an alkyne moiety. It is readily inserted into newly-synthesized proteins in place of methionine. L-Homopropargyl glycine can then be labeled or captured through click chemistry. This approach represents a fast, sensitive, and non-radioactive alternative to [³⁵S]-methionine for the detection of nascent protein synthesis.

L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor[1][2].

Alkyl-Chain

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
[2] Shen Y, et al. Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc. 2021;2(3):100616. Published 2021 Jun 17. DOI:10.1016/j.xpro.2021.100616