α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide.1 It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 in mouse splenocytes in vitro and in mouse serum following administration of a 1 μg per animal dose, indicating a Th2 response.
References
1. Lee, T., Cho, M., Ko, S.-Y., et al. Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant α-GalCer J. Med. Chem. 50(3),585-589(2007).
