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91-22-5

Name Quinoline
CAS 91-22-5
EINECS(EC#) 202-051-6
Molecular Formula C9H7N
MDL Number MFCD00006736
Molecular Weight 129.16
MOL File 91-22-5.mol

Chemical Properties

Description
Quinoline is a colourless hygroscopic liquid with characteristic odour. On exposure to light, it turns brown in colour. Quinoline decomposes on heating, and on burning produces toxic fumes including nitrogen oxides. Quinoline reacts with strong oxidants, acids, and anhydrides. Quinoline is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents. Quinoline is combustible. It gives off irritating or toxic fumes (or gases) in a fire. Quinoline is incompatible with strong acids, oxidisers, dinitrogen tetroxide, linseed oil, thionyl chloride, maleic anhydride, and perchromates and reacts violently with most incompatibles. Quinoline is used extensively in the manufacturing of dyes, preparation of hydroxyquinoline sulphate and niacin, as a solvent for resins and terpenes, and as an intermediate in the manufacture of other products.
Quinoline is used mainly as an intermediate in the manufacture of other several products, as a catalyst, as a corrosion inhibitor, in metallurgical processes, in the manufacture of dyes, as a preservative for anatomical specimens, in polymers and agricultural chemicals, and as a solvent for resins and terpenes. Quinoline is also used as an anti-malarial medicine. Because of its solubility in water, quinoline has significant potential for mobility in the environment, which may promote water contamination. Potential exposure to quinoline also occurs from the inhalation of cigarette smoke. Quinoline breaks down quickly in the atmosphere and water.
Appearance Quinoline is a colorless liquid with a penetrating amine odor. Turns brown on exposure to light.
Melting point  -17--13 °C (lit.)
Boiling point  113-114 °C/11 mmHg (lit.) 237 °C (lit.)
density  1.093 g/mL at 25 °C(lit.)
vapor density  4.5 (vs air)
vapor pressure  0.07 mm Hg ( 20 °C)
FEMA  3470
refractive index  n20/D 1.625(lit.)
Fp  214 °F
storage temp.  Store below +30°C.
solubility  6g/l
form  Liquid
pka 4.9(at 20℃)
color  Purple to dark grey
Odor Strong, unpleasant.
PH 7.3 (5g/l, H2O, 20℃)
Stability: Stable. Incompatible with strong acids, strong oxidizing agents. May discolour on exposure to light. Hygroscopic-protect from moisture. Reacts violently and unpredictably with some materials, especially strong oxidizing agents.
explosive limit 1.2-7%(V)
Odor Type medicinal
Water Solubility  slightly soluble
Sensitive  Light Sensitive & Hygroscopic
Merck  14,8068
BRN  107477
Dielectric constant 2.6(-180℃)
InChIKey SMWDFEZZVXVKRB-UHFFFAOYSA-N
LogP 2.04 at 22℃
Uses
Preserving anatomical specimens; manufac- ture of quinolinol sulfate; niacin and copper-8- quinolinolate; flavoring.
CAS DataBase Reference 91-22-5(CAS DataBase Reference)
IARC 2B (Vol. 121) 2019
NIST Chemistry Reference Quinoline(91-22-5)
EPA Substance Registry System 91-22-5(EPA Substance)

Safety Data

Hazard Codes  Xn
Risk Statements 
R21/22:Harmful in contact with skin and if swallowed .
R38:Irritating to the skin.
R41:Risk of serious damage to eyes.
R68:Possible risk of irreversible effects.
R40:Limited evidence of a carcinogenic effect.
R37/38:Irritating to respiratory system and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
RIDADR  UN 2656 6.1/PG 3
WGK Germany  2
RTECS  VA9275000
8
Autoignition Temperature 896 °F
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29334900
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. Moderately toxic by skin contact. A skin and severe eye irritant. Mutation data reported. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. It can cause retinitis sdar to that caused by naphthalene but without causing opacity of the lens. Combustible when exposed to heat or flame. Its preparation has caused many industrial explosions. Potentially explosive reaction with hydrogen peroxide. Violent reaction with dmtrogen tetraoxide, perchromates. Incompatible with linseed oil + thionyl chloride, maleic anhydride, Unpredctably violent. When heated to decomposition it emits toxic fumes of NOx.
Hazardous Substances Data 91-22-5(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 460 mg/kg (Smyth)

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