Chemical Properties
Yellow to amber liquid
Uses
A non ionic detergent for cell lysis
Uses
Glycolube(R) AFA-1 is used as an antistat for PVC and as an antifog for PP, PE, PVC, PS.
Uses
Glycosperse(R) O-20 KFG is used as an emulsifier (ice cream, whipped topping) and as a solubilizing and dispersing agent in pickles and special vitamin-mineral preparations. Product Data Sheet
Uses
Lonzest(R) SMO-20 is used as an emulsifier for textiles, personal care and industrial applications.
Uses
Lonzest(R) SMO-5 is a general purpose mid-range HLB, ethoxylated, nonionic surfactant suggested for use in textile chemicals (emulsifier, lubricant), household products and cosmetic formulations (o/w emulsifier, viscosity modifier).
Uses
Vinylube(R) 38 is an external lubricant for PVC bottle, film, and sheet components with excellent processing abilities and final clarity. It is also used as an antistatic agent. Product Data Sheet
General Description
Amber-colored viscous liquid. pH (5% aqueous solution) 5-7. Faint odor and bitter taste.
Air & Water Reactions
Water soluble.
Reactivity Profile
Tween 80 is incompatible with strong alkalis and oxidizers.
Fire Hazard
Tween 80 is probably combustible.
Characteristics
Tween-80, commercially known as Polysorbate-80, is a viscous, water-soluble Yellow to amber liquid derived from polyethoxylated sorbitan and oleic acid. Tween-80 is structurally similar to the (polyethylene) glycols and used both in injections (0.8-8.0%) and in oral suspension (0.375% w/v). A number of anticancer drugs can be formulated by Tween-80. Typical examples include etoposide and minor groove-binding cyclopropylpyrroloindole analogues like carzelesin.
Definition
ChEBI: A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group.
Brand name
Sorlate (Abbott); Tween 80 (ICI Americas).
Biochem/physiol Actions
Polysorbates is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.
Pharmacokinetics
Polysorbate 80 (Tween 80) is rapidly removed from systemic circulation. The polysorbate 80 plasma concentration-time curve (AUC) in a patient administered an intravenous (IV) infusion of docetaxel 35 mg/m2 (polysorbate 80 1.75 g) showed a polysorbate 80 peak concentration of 304 μg/ml. The AUC for polysorbate 80 was 321.7 mg h/ml, with a short disposition half-life of 1.07 h and a total plasma clearance of 5.44 l/h. The distribution of polysorbate 80 at steady state was similar to the total blood volume (4.16 l), suggesting that polysorbate 80 circulates as large micelles and does not significantly distribute outside the central compartment. In vitro studies suggest that polysorbate 80 is metabolized by rapid carboxylesterase-mediated hydrolysis[1].
