Example 2: Preparation of 2-amino-5-bromo-4,6-dimethylpyridine (13): 2.00 g (16.32 mmol) of 2-amino-4,6-dimethylpyridine was dissolved in 25 mL of acetonitrile under argon protection and 2.90 g (16.32 mmol) of N-bromosuccinimide was added with stirring. The reaction mixture was stirred at room temperature for 5 hours. Upon completion of the reaction, the resulting precipitate was collected by filtration and dried to afford the target product 2-amino-5-bromo-4,6-dimethylpyridine as a white solid in a yield of 2.76 g (84% yield). The structure of the product was confirmed by 1H-NMR (CDCl3) δ 6.22 (s, 1H), 4.39 (br, 2H), 2.48 (s, 3H), 2.25 (s, 3H) and 13C-NMR (CDCl3) δ 156.34, 155.23, 148.64, 112.26, 108.10, 25.10, 23.30.
