MAO-B-IN-37 (Compound 37) is a derivative of TT01001 (HY-114520), and a selective inhibitor for monoamine oxidase B (MAO-B) with an IC50 of 270 nM. MAO-B-IN-37 exhibits good metabolic stability in mice microsomes and good affinity with human serum albumin[1].
IC 50
MAO-B: 0.27 μM (IC50); MAO-A: 16 μM (IC50)
References
[1] Barbosa Belchior M, et al., Synthesis and evaluation of enzyme inhibition by novel TT01001 derivatives as monoamine oxidase B inhibitors. Bioorg Med Chem Lett. 2024 Dec 2;117:130045. DOI:10.1016/j.bmcl.2024.130045
