869376-90-9

CB-52 is a stable analog of Δ⁹-tetrahydrocannabinol (THC) and anandamide (AEA). It exhibits high affinity for the central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) receptors with K_i values of 210 and 30 nM, respectively.¹ In vitro, CB-52 behaves primarily as a CB₁ receptor partial agonist and a CB₂ receptor neutral antagonist.²

CB-52 is the ligand and neutral antagonist of CB2 cannabinoid receptor[1].

1. Brizzi, A., Brizzi, V., Cascio, M.G., et al. Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors J. Med. Chem. 48,7343-7350(2005).
2. Cascio, M.G., Bisogno, T., Palazzo, E., et al. In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands Br. J. Pharmacol. 149,431-440(2006).