86727-00-6

CK 17 is a interleukin-1 antagonist. It is a IL-1 blocker that suppresses fibroblast proliferation in a concentration-dependent manner.

CK-17 is an orally active and potent anti-inflammatory agent. CK-17 shows potent inhibition of ocular inflammation induced by lens protein, endotoxin, and IL-1. The effects on IL-1-induced inflammation are about 2 fold more potent than Prednisolone (HY-17463)[1].

[1] Chiou GC, et al. Prevention of ocular inflammation induced by lens protein, endotoxin, and interleukin-1 with synthetic interleukin-1 blockers. J Ocul Pharmacol. 1994 Fall;10(3):577-86. DOI:10.1089/jop.1994.10.577