865092-05-3

Gymnoascolide A, identified as a fungal metabolite in M. filamentosa, demonstrates vasodilatory effects. At a concentration of 1 μM, it effectively inhibits contractions induced by calcium in isolated rat aortic rings[1].

Gymnoascolide A is a fungal metabolite originally isolated from G. reessii that has fungicidal and vasodilatory activities.1,2 It is active against the phytopathogenic fungus S. nodorum (MIC = 13 μg/ml) but not C. albicans, B. subtilis, or the ruminant pathogenic nematode H. contortus in an agar diffusion assay.1,2 Gymnoascolide A (1 μM) inhibits calcium-induced contractions in isolated rat aortic rings.2

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1.Clark, B., Capon, R.J., Lacey, E., et al.Gymnoascolides A-C: Aromatic butenolides from an Australian isolate of the soil Ascomycete Gymnoascus reessiiJ. Nat. Prod.68(8)1226-1230(2005) 2.Hosoe, T., Iizuka, T., Komai, S., et al.4-Benzyl-3-phenyl-5H-furan-2-one, a vasodilator isolated from Malbranchea filamentosa IFM 41300Phytochem.66(23)2776-2779(2005)