Under nitrogen protection, 1,4-dioxane (400 mL), 5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine (20.0 g, 83.3 mmol, 1.0 equiv), bis(pinacolato)diboron (25.3 g, 100 mmol, 1.2 equiv), potassium acetate (20.4 g, 208 mmol, 2.5 equivalent) and bis(triphenylphosphine)dichloropalladium (1.17 g, 1.4 mmol, 0.015 equivalent). The reaction mixture was heated to reflux and the progress of the reaction was monitored by TLC using 5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine as reference. Upon completion of the reaction, it was cooled to below 20°C. Subsequently, (5R)-3-(4-bromo-3-fluorophenyl)-5-hydroxymethoxazolidin-2-one (21.7 g, 75.0 mmol, 0.9 equiv), potassium carbonate (34.5 g, 250 mmol, 3.0 equiv), palladium acetate (0.14 g, 0.62 mmol, 0.0075 equiv), and triphenylphosphine ( 0.65 g, 2.5 mmol, 0.03 eq.) and warmed to reflux under nitrogen protection. The progress of the reaction of 2-(2-methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine was tracked by TLC until completion. After completion of the reaction, it was cooled to room temperature and stirred for 16 hours. The reaction was filtered under reduced pressure and the filter cake was washed sequentially with water (200 mL) and methanol (200 mL). The filter cake was collected and air dried at 80°C to afford 25.8 g of the target product (R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one (Compound I) as an off-white powder in 84% yield.