85326-10-9

N-Isobutyryl-5'-O-tert-butyldimethylsilyl-2'-deoxyguanosine can be used to activate proteins, receptors, and ion channels. It has been shown to bind to the receptor site on the cell membrane, which may inhibit the binding of ligands and then initiate signal transduction. N2-Isobutyryl-5'-o-(tert-butyldimethylsilyl)-2'-deoxyguanosine has been shown to inhibit protein interactions, such as antibody binding and peptide binding. This ligand also inhibits the activity of ion channels in a dose-dependent manner.

5'-O-TBDMS-N2-ibu-dG is a nucleoside derivative and can be used for lead compounds synthesis with anti-bovine viral diarrhea virus activity[1].

[1] Kohji Seio, et al. Synthesis of benzodithiol-2-yl-substituted nucleoside derivatives as lead compounds having anti-bovine viral diarrhea virus activity. J Med Chem. 2004 Oct 7;47(21):5265-75. DOI:10.1021/jm049677d