852045-46-6

FLT3 Inhibitor III is a potent inhibitor of Fms-like tyrosine kinase 3 (FLT3; IC₅₀ = 50 nM). It shows high selectivity for FLT3 over a panel of 300 other kinases. FLT3 Inhibitor III blocks FLT-dependent cell proliferation in a dose-dependent manner. FLT3 Inhibitor III has been used to study signaling through FLT3 and FLT3 with internal tandem duplications (FLT3-ITD) in cells.