Rocaglamide is an anti-
inflammatory, insecticidal, and anticancer tetrahydrobenzofuran isolated from
Aglaia species. It has been shown to inhibit both TNF-
α and the activation of NF-
κB in Jurkat T cells with IC
50 values in the nanomolar range.
1 At 25 nM, rocaglamide induces apoptosis in various human leukemia cell lines, activating p38 MAPK/JNK and suppressing ERK.
2 Rocaglamide also reduces IFN-
γ, TNF-
α, IL-
2, and IL-
4 production in peripheral blood T cells at a concentration of 50 nM.
3 Furthermore, rocaglamide can inhibit the T cell expression of the immune response transcription factor, nuclear factor of activated T cells.
3