General Description
Light yellow crystalline solid. Insoluble in water.
Reactivity Profile
A nitrated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.
Air & Water Reactions
Insoluble in water.
Fire Hazard
Flash point data is not available for this compound, however, MUSK KETONE is probably combustible.
Chemical Properties
It forms yellowish crystals with a sweet, very
persistent, slightly animal musk odor.Musk ketone is prepared by Friedel–Crafts
acetylation of 1,3-dimethyl-5-tert-butylbenzene and nitration of the resulting 2,6-
dimethyl-4-tert-butylacetophenone with nitric acid.
Musk ketone is widely used as a fixative in blossom and fantasy compositions.
Chemical Properties
White to light yellow crystal powde
Occurrence
Has apparently not been reported to occur in nature.
Uses
Musk ketone is used as fragrance and fixative in after-shave lotions, perfumes, ete.
Definition
ChEBI: 4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone is an aromatic ketone.
Preparation
Nitration of the corresponding benzene derivative (Bedoukian, 1967).
Flammability and Explosibility
Notclassified(100%)
Purification Methods
Purify the ketone by recrystallisation from MeOH. It has a strong odour of musk and is used in perfumery. [Fuson et al. J Org Chem 12 587 1947, Beilstein 7 IV 808.]
