Chemical Properties
clear yellowish viscous liquid
General Description
Pale yellow oily liquid with a weak odor of peanuts. Floats on water. Contains principally glycerides of oleic and linoleic acids.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
PEANUT OIL react with acids to liberate heat. Heat is also generated by interaction with caustic solutions. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Flammable hydrogen is generated by mixing with alkali metals and hydrides. React slowly with oxygen in the air to become rancid.
Health Hazard
None-is a food.
Definition
Extractives and their physically modified derivatives. It consists primarily of the glycerides of the fatty acids arachidic, behenic, lignoceric, linoleic, oleic, palmitic and stearic.
Production Methods
Refined peanut oil is obtained from the seeds of Arachis hypogaea
Linne′ (Fam. Leguminosae). The seeds are separated from the peanut
shells and are expressed in a powerful hydraulic press. The crude oil
has a light yellow to light brown color, and is then purified to make
it suitable for food or pharmaceutical purposes. A suitable
antioxidant may be added.
Pharmaceutical Applications
Peanut oil is used as an excipient in pharmaceutical formulations
primarily as a solvent for sustained-release intramuscular injections.
It is also used as a vehicle for topical preparations and as a solvent
for vitamins and hormones. In addition, it has been part of
sustained-release bead formulations,nasal drug delivery systems,and controlled-release injectables.
Therapeutically, emulsions containing peanut oil have been used
in nutrition regimens, in enemas as a fecal softener, and in otic drops
to soften ear wax. It is also administered orally, usually with
sorbitol, as a gall bladder evacuant prior to cholecystography.
Peanut oil is also widely used as an edible oil.
Biochem/physiol Actions
Peanut oil (20% in the diet) reduces plasma total cholesterol, low-density lipoprotein cholesterol without affecting high-density cholesterol in the plasma when fed to male Syrian golden hamsters at 12 weeks after feeding . Peanut oil feeding also retards the increase in aortic total cholesterol and cholesteryl ester, suggesting that peanut oil delays the development of atherosclerosis in animals consuming an atherosclerosis inducing diet.
Safety
Peanut oil is mildly laxative at a dosage of 15–60mL orally or of
100–500mL rectally as an enema.
Adverse reactions to peanut oil in foods and pharmaceutical
formulations have been reported extensively.These include
severe allergic skin rashes and anaphylactic shock following
consumption of peanut butter.Some workers have suggested
that the use in infancy of preparations containing peanut oil,
including infant formula and topical preparations, is associated
with sensitization to peanut, with a subsequent risk of hypersensitivity
reactions, and that such products should therefore be avoided
or banned.However, the role of pharmaceutical preparations
in later development of hypersensitivity is disputed since such
preparations contain highly refined peanut oil that should not
contain the proteins associated with allergic reactions in susceptible
individuals.
Peanut oil is harmful if administered intravenously and it should
not be used in such formulations.
storage
Peanut oil is an essentially stable material.However on exposure
to air it can slowly thicken and may become rancid. Solidified
peanut oil should be completely melted and mixed before use.
Peanut oil may be sterilized by aseptic filtration or by dry heat, for
example, by maintaining it at 150°C for 1 hour.
Peanut oil should be stored in a well-filled, airtight, lightresistant
container, at a temperature not exceeding 40°C. Material
intended for use in parenteral dosage forms should be stored in a
glass container.
Incompatibilities
Peanut oil may be saponified by alkali hydroxides.
Regulatory Status
Included in the FDA Inactive Ingredients Database (IM injections,
topical preparations, oral capsules, and vaginal emulsions).
Included in parenteral and nonparenteral medicines licensed in the
UK. Included in the Canadian List of Acceptable Non-medicinal
Ingredients.