General procedure: butylmagnesium bromide was prepared according to the literature method. Under nitrogen protection, magnesium bromide diethyl ether compound (0.28 g, 1.08 mmol) was slowly added to a dichloromethane solution (2 mL) of (2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-ethanone (0.10 g, 0.45 mmol) in stirring. The reaction mixture was stirred at room temperature for 90 min and then cooled to 0°C, followed by the slow dropwise addition of an ether solution of methylmagnesium bromide (3.0 M, 0.41 mL, 1.21 mmol). The reaction system was slowly warmed to room temperature and stirring was continued for 12 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (2 mL) and extracted with dichloromethane (3 x 5 mL). The organic phases were combined and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent: methanol/dichloromethane=5:95, Rf=0.20) to afford the target compound 2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol (0.035 g, 33% yield) as a white solid.
