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MRS3558 is an A3 adenosine receptors Agonist.

MRS3558 is a potent and selective A3AR agonist, with Ki values of 0.6 nM for humans and 0.9 nM for rats, making it suitable for research in the fields of neuropathic pain and anesthesia[1].

hA_2AAR: 0.6 nM (Ki); rA_2A: 0.9 nM (Ki)

[1] Kiesewetter D O, et al. Synthesis and characterization of [76Br]-labeled high-affinity A3 adenosine receptor ligands for positron emission tomography[J]. Nuclear medicine and biology, 2009, 36(1): 3-10. DOI:10.1016/j.nucmedbio.2008.10.003