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783355-60-2

Supplier Related Products Identification Chemical Properties Hazard Information

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Identification

Name
CRA-02478
CAS
783355-60-2
Synonyms
CS-423
CRA 24781
CRA-02478
PCI-24781
CRA 024781
Abexinostat
PCI-24781, >=98%
PCI-24781;CRA-02478
CRA-02478 PCI-24781
PCI-24781(CRA-024781)
Abexinostat(PCI-24781)
PCI-24781 (Abexinostat)
CRA 024781;CRA 24781;ABEXINOSTAT
PCI-24781 (ABEXINOSTAT);PCI 24781
CRA 024781;CRA 24781;PCI 24781;ABEXINOSTAT
CRA-024781; CRA 024781; CRA024781; PCI24781; PCI-24781; PCI 24781; ABEXINOSTAT.
3-((diMethylaMino)Methyl)-N-(2-(4-(hydroxycarbaMoyl)phenoxy)ethyl)benzofuran-2-carboxaMide
3-[(dimethylamino)methyl]-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide
3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide
2-Benzofurancarboxamide, 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-
3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide PCI-24781
EINECS(EC#)
811-183-9
Molecular Formula
C21H23N3O5
MDL Number
MFCD10565969
MOL File
783355-60-2.mol
Molecular Weight
397.42

Chemical Properties

density 
1.284

Hazard Information

Uses
PCI-24781 is a novel hydroxamic acid HDAC inhibitor (histone deacetylase inhibitor). ?PCI-24781 exerts cytotoxicity and histone H3 alterations via caspase-8 and FADD in leukemia cells.
Enzyme inhibitor
This broad-spectrum histone deacetylase inhibitor (FW = 394.48 g/mol; CASs = 783355-60-2, 783356-67-2 (HCl)); Solubility: 80 mg/mL DMSO; <1 mg/mL Water; Formulated in 30% HP-cyclodextrin in water), also known as CRA-024781 and systematically as 3-((dimethylamino)methyl)- N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)benzofuran-2-carboxamide, is a novel broad-spectrum HDAC inhibitor targeting HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki of 7 nM, 19 nM, 8.2 nM, 17 nM, 280 nM, 24 nM, respectively. PCI-24781 treatment causes dosedependent accumulation of both acetylated histones and acetylated tubulin in HCT116 or DLD-1 cells. It also induces expression of p21 and leads to PARP cleavage and accumulation of the γH2AX.
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