General Description
Yellow-pink crystals or off-white powder. Sensitive to light.
Reactivity Profile
N-NITROSO-N-ETHYLUREA(759-73-9) is highly reactive. Sensitive to moisture and light. Its stability in aqueous solutions is pH-dependent. Incompatible with water and nucleophilic reagents. Alkaline hydrolysis produces a highly explosive gas. .
Air & Water Reactions
Water soluble. Sensitive to moisture--stability in aqueous solutions depends on pH.
Hazard
Tumorigen, carcinogen, neoplastigen; teratogen; poison; toxic.
Health Hazard
ACUTE/CHRONIC HAZARDS: This compound is extremely unstable at high pH. It will decompose to extremely unstable decomposition products if acidic conditions are not maintained. When heated to decomposition it emits toxic fumes of nitrogen oxides. Decomposition products may be explosive.
Potential Exposure
Used as a chemical intermediate for
dyes and pharmaceuticals; a polymerization inhibitor during
the manufacture of vinyl monomers such as styrene; a
precursor of diazoethane; accelerator for rubber vulcanization.
Fire Hazard
Flash point data for this chemical are not available; however, N-NITROSO-N-ETHYLUREA is probably combustible.
First aid
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical
attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
Shipping
Toxic solids, organic, n.o.s., Hazard Class: 6.1;
Labels: 6.1-Poisonous materials, Technical Name Required.
UN3077 Environmentally hazardous substances, solid,
n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous
material, Technical Name Required.
Incompatibilities
N-nitroso-N-ethylurea is highly reactive.
Sensitive to moisture and light. Its stability in aqueous
solutions is pH-dependent. Incompatible with water and
nucleophilic reagents. Alkaline hydrolysis produces a
highly explosive gas. This compound is extremely
unstable at high pH. It will decompose to extremely
unstable decomposition products if acidic conditions are
not maintained. Nitrated organics range from slight to
strong oxidizing agents. If mixed with reducing agents,
including hydrides, sulfides and nitrides, they may begin a
vigorous reaction. Reaction with
Chemical Properties
N-Nitroso-N-ethyl urea is a pale yellow, crystalline
powder; freezing/melting point=103－104°C
(decomposes). Hazard identification (based on NFPA-704
M Rating System): Health 2; flammability 1; reactivity 0?.
Soluble in water; hydrolysis produces explosive gas.
Chemical Properties
Orange Paste
Waste Disposal
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations
governing storage, transportation, treatment, and waste
disposal.
Uses
N-Nitroso-N-ethylurea has been used as a mutation-inducing agent.
Uses
A precursor of Diazoethane
Uses
Experimentally as mutagen; ethylating agent.
Definition
ChEBI: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.
Biochem/physiol Actions
DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.
Carcinogenicity
N-Nitroso-N-ethylurea is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
