701225-07-2

Name	3-(4-oxo-3(4H)-quinazolinyl)-N-[4-(1-piperidinylsulfonyl)phenyl]propanamide
CAS	701225-07-2
Molecular Formula	C22H24N4O4S
Molecular Weight	440.52
MOL File	701225-07-2.mol

Synonyms

IRF1-IN-1 3(4H)-Quinazolinepropanamide, 4-oxo-N-[4-(1-piperidinylsulfonyl)phenyl]- 3-(4-oxo-3(4H)-quinazolinyl)-N-[4-(1-piperidinylsulfonyl)phenyl]propanamide 3-(4-oxoquinazolin-3(4H)-yl)-N-[4-(piperidin-1-ylsulfonyl)phenyl]propanamide

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Chemical Properties

density	1.38±0.1 g/cm3(Predicted)
form	Solid
pka	13.83±0.70(Predicted)
color	White to off-white

Hazard Information

Uses

IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor. IRF1-IN-1 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-1 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1). IRF1-IN-1 has a protective effect on ionizing radiation-induced inflammatory skin injury[1].

in vivo

IRF1-IN-1 pretreatment (100?μg/d, s.c., one every other day before irradiation) has a potential protective effect in 35 Gy radiation-induced inflammatory skin injury mice^[1].

Animal Model:	Radiogenic skin injury mice (intraperitoneal injection of pentobarbital sodium (1%, 30 mg/kg), 35 Gy at the dose rate of 1000 cGy/min by a 6-MeV electron beam)^[1]
Dosage:	100 μg/d
Administration:	Subcutaneous injection (s.c.), one every other day before irradiation, pretreatment
Result:	Showed a significant reduction in acute skin inflammatory manifestations, such as erythema and exudation and accelerated the healing process. Showed protective effects on the function and structural integrity of radiation-induced lesions to the claws.

IC 50

PARP-1; IL-1; Caspase-1

References

[1] Geng, et al. Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response. Cell Mol Immunol. 2024 Aug;21(8):856-872. DOI:10.1038/s41423-024-01185-3

Supplier

Jinan Jiuli Biotechnology Co. , Ltd.

Telephone 15865264761

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList89365/0.htm

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