696-02-6

108-90-7

348-51-6

352-33-0

625-98-9

1435-44-5

696-02-6

2367-91-1

GENERAL STEPS: In a FEP or PFA reactor equipped with a PTFE-lined magnetic stir bar and connected to a gas scrubber bottle, substituted benzene (0.95-1.10 mmol), 1,1,1,3,3-pentafluorobutane (2 mL per mL of C6H5R), and BF3-Et2O (1.3-1.5 mmol/mmol C6H5R) were added. The mixture was stirred at 0-5 °C (ice bath) for 10-15 min, followed by the addition of XeF2 (1.2-1.3 mmol/mmol C6H5R) in batches. After each addition, the mixture was stirred at 22-25 °C for 3-5 min and recooled. After all XeF2 was added, the resulting dark-colored solution was continued to be stirred at 22-25 °C for 15-30 min. Upon completion of the reaction, the reaction was quenched by the addition of 10% aqueous KHCO3, the organic layer was separated and filtered through a short column packed with silica gel (40-60 μm) and finally dried over magnesium sulfate. The resulting solution was analyzed by 19F NMR and GC/MS. The major products are listed in the table and the remaining products are as follows (with GC/MS data).