Description
Sulbactam sodium is a parenterally-active, β-lactamase inhibitor recently
introduced as a 1: 1 combination product with cefoperazone. Like clavulanic acid,
the first agent of this type to b e introduced, sulbactam enhances the effectiveness
of β-lactam antibiotics against resistant strains.
Chemical Properties
White Solid
Uses
A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial.
Definition
ChEBI:Sulbactam sodium is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.
Manufacturing Process
Sulbactam sodium is semi-synthetic antibiotic of penicillinic group. Start
material for it's synthesis is 6-aminopenicillanic acid. First 6-aminopenicillanic
acid was isolated in 1957 year from benzylpenicilline as resalt of treating of it
by penicillinaze. Benzylpenicilline is produced by microorganism of genus
Streptomyces.
Further, 6-aminopenicillanic acid reacted with bromine, hydrochloric acid and
NaNO2. As a result the 6,6-dibromopenicillanic acid was obtained.
6,6-Dibromopenicillanic acid was oxidized by KMnO4, to give 6,6-dibromo-1,1-The 6,6-dibromo-1,1-dioxopenicillanic acid in presence of Fe was converted to
the 1,1-dioxopenicillanic acid (sulbactam acid). The sulbactam acid was
treated by sodium 2-ethylhexanoate and crude sulbactam sodium was
obtained.
Therapeutic Function
Beta-lactamase inhibitor
Safety Profile
Poison by intravenous route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx
storage
Store at -20°C, protect from light, stored under nitrogen
