690655-41-5

Name	NCX899
CAS	690655-41-5
Molecular Formula	C23H33N3O8
MDL Number	MFCD31382168
Molecular Weight	479.52
MOL File	690655-41-5.mol

Synonyms

NCX899 L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-, 3-(nitrooxy)propyl ester

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Chemical Properties

Boiling point	622.7±55.0 °C(Predicted)
density	1.229±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	5.43±0.39(Predicted)

Hazard Information

Uses

NCX899 is a NO-releasing derivative of enalapril, and shows inhibitory activity against angiotensin-converting enzyme (ACE) activity.

in vivo

NCX 899 (NCX, 25 mg/kg, n=10) decreases the end-diastolic dimension in cardiomyopathic (CM) with heart failure. NCX 899 inhibits ACE activity and increases the plasma nitrate levels in CM hamster^[1]. NCX899 (4 micromol/kg, i.v.) inhibits the activity of serum angiotensin-converting enzyme in dogs. NCX899 significantly attenuates both arterial hypertension and bradycardia^[2].

References

[1] Iwanaga Y, et al. A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure. FASEB J. 2004 Mar;18(3):587-8. Epub 2004 Jan 20. DOI:10.1096/fj.03-0872fje
[2] Okuyama CE, et al. Pharmacokinetics and pharmacodynamics of a nitric oxide-releasing derivative of enalapril in male beagles. Clin Exp Pharmacol Physiol. 2007 Apr;34(4):290-5. DOI:10.1111/j.1440-1681.2007.04559.x

Supplier

Fan De(Beijing) Biotechnology Co., Ltd.

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