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68-26-8

Name VITAMIN A
CAS 68-26-8
EINECS(EC#) 200-683-7
Molecular Formula C20H30O
MDL Number MFCD00001552
Molecular Weight 286.45
MOL File 68-26-8.mol

Chemical Properties

Appearance Yellow-Orange Powder
Melting point  61-63 °C(lit.)
mp  61-63 °C(lit.)
Boiling point  368.81°C (rough estimate)
density  0.9933 (rough estimate)
refractive index  1.641
Fp  -26 °C
storage temp.  2-8°C
solubility  Chloroform (Slightly), Methanol (Slightly)
form  crystalline
pka 14.09±0.10(Predicted)
color  yellow to orange
Stability: Stable, but light and air sensitive. Incompatible with strong acids, strong oxidizing agents.
Water Solubility  Practically insoluble inwaterorglycerol; soluble in absolute alcohol,methanol,℃hloroform, ether, fats and oils.
Sensitive  Moisture & Light Sensitive
Merck  13,10073
BRN  403040
Uses

retinol is a retinoid considered to be a skin revitalizer. It is reported to enhance skin radiance and treat conditions associated with chronological aging, such as wrinkles and fine lines, as well as dermatological disorders, including acne, follicular and lesion papules, actinic keratosis, oily skin, and rosacea. According to clinical dermatologists, retinol is one of the few substances with a demonstrated ability to reduce and prevent fine lines and wrinkles. It is able to alter the behavior of aged cells so they act in a more youthful manner. It is considered necessary for normal epidermal cell growth and differentiation and stimulates the production of new blood vessels in the skin, improving skin tone. In addition, retinol has anti-oxidant capacities and protects dermal fibers by counteracting the increased activity of enzymes that degrade collagen and elastin when the skin is exposed to uV rays. Retinol can be drying to the skin when used for a prolonged period of time or in concentrations that are too high. A weaker retinoid than retinoic acid, retinol converts to retinoic acid once on the skin. When compared to retinoic acid, retinol has an increased penetration potential and is less irritating, making it an effective ingredient for anti-aging products. The anti-aging benefits of topically treating skin with retinol are based on its penetration ability, which allows it to reach the sites in the skin requiring treatment. When used on sensitive skin for a prolonged period of time or in concentrations that are too high, retinol can cause dermatitis.

CAS DataBase Reference 68-26-8(CAS DataBase Reference)
EPA Substance Registry System Retinol (68-26-8)

Safety Data

Hazard Codes  Xn,N,F
Risk Statements 

R22:Harmful if swallowed.
R38:Irritating to the skin.
R67:Vapors may cause drowsiness and dizziness.
R65:Harmful: May cause lung damage if swallowed.
R62:Possible risk of impaired fertility.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R48/20:Harmful: danger of serious damage to health by prolonged exposure through inhalation .
R11:Highly Flammable.

Safety Statements 

S36/37:Wear suitable protective clothing and gloves .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S62:If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label .

RIDADR  UN 1208 3/PG 2
WGK Germany  3
RTECS  VH6750000
8-10-16-23
TSCA  Yes
HS Code  29362100
Safety Profile

Moderately toxic by ingestion. Human teratogenic effects by ingestion: developmental abnormalities of the craniofacial area and urogenital system. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Hazardous Substances Data 68-26-8(Hazardous Substances Data)
Toxicity

LD50 (10 day) in mice (mg/kg): 1510 i.p.; 2570 orally (Kamm)

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