Description
PGF2α dimethyl amine is a derivative of PGF2α which was designed as a PG antagonist for in vitro and in vivo studies. PGF2α dimethyl amine is a weak FP receptor antagonist. In gerbil colon, PGF2α dimethyl amine at a dose of 3.2 μg/ml inhibits the contractile effects of PGF2α (at 6 ng/ml) by 60%.
Uses
Prostaglandin F2α dimethyl amine is a Prostaglandin F2α (HY-12956) derivative. Prostaglandin F2α dimethyl amine is an antagonist for Prostaglandin F receptor (FP)[1]. Prostaglandin F2α dimethyl amine blocks the cardiovascular responses induced by orexin and Arachidonic acid (HY-109590)[2].
Definition
ChEBI: A member of the class of prostaglandins Falpha that is the dimethylamine derivative of prostaglandin F2alpha.
in vivo
Prostaglandin F2α dimethyl amine (50 μg, i.c.v., single dose) prevents the pressor and tachycardic effects induced by Orexin in Sprague-Dawley rats[2].
| Animal Model: |
Orexin-induced cardiovascular response in Sprague Dawley rats[2] |
| Dosage: | 50 μg |
| Administration: | i.c.v for single dose |
| Result: | Prevented the pressor and tachycardic effects. |
References
[1] Griffin BW, et al., AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor. J Pharmacol Exp Ther. 1999 Sep;290(3):1278-84. PMID:10454504
[2] ALTINBA? B. The Intermediation Role of Central Cyclooxygenase Products TXA2, PGF2α, PGE, and PGD in Orexin-evoked Cardiovascular Effects[J]. Izmir Democracy University Health Sciences Journal, 2021, 4(3): 251-266.
