635-65-4

Name	Bilirubin
CAS	635-65-4
EINECS(EC#)	211-239-7
Molecular Formula	C33H36N4O6
MDL Number	MFCD00005499
Molecular Weight	584.66
MOL File	635-65-4.mol

Synonyms

BILIRUBIN filirubin Bilibubin Biliyubin HEMATOIDIN hemetoidin 1,19-dioxo- BilirubinGr Cholerythrin Bilirubin,99% Bilirubin,97% Bilirubin IXa (Z,Z)-Bilirubin Obeticholic Acid2 bilirubinix-alpha BILIRUBIN (ALPHA) BILIRUBIN (EX PIG) BILIRUBIN STANDARD Bilirubin, 99% 1GR Bilirubin, 99% 500MG principalbilepigment 18-divinyl-19-dioxo-3 BILIRUBIN extrapure AR Bilirubin from Porcine BILIRUBIN REAGENT-GRADE BILIRUBIN MIXED ISOMERS Bilirubin, synthesis grade ,13,18-tetramethyl-1,19-dioxo- BILIRUBIN LIN-TROL TOTAL & DIRECT BILIRUBIN LIN-TROL PREDILUTED SET D-BiotinForBiochemistry(VitaminH) BILIRUBIN CALIBRATOR, TOTAL & DIRECT BILIRUBIN CONTROL, TOTAL AND DIRECT*NORMAL BILIRUBIN CONTROL, TOTAL AND DIRECT*ELEVATED 21H-Biline-8,12-dipropanoicacid,2,17-diethenyl- 1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl- 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-biline-12-dipropionicacid 21h-biline-8,12-dipropanoicacid,2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7 3-{2-({3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylid Biline-8,12-dipropionic acid, 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl- 1，10，19，22，23，24-hexahydro-2，7，13，17-tetramethyl-1，19-dioxo-3，18-divinylbilidiene-8，12-dipropionic acid 2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetrametyl-1,19-dioxo-21H-biline-8,12-dipropanoic Acid 12-dipropanoicacid,2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8 2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid 21H-BILINE-8,12-DIPROPANOIC ACID,2,17-DIETHENYL-1,10,19,22,23,24-HEXAHYDRO-3,7,13,18-TETRAMETHYL-1,19-DIOXO- 12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8 21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo- BILIRUBIN: 21H-BILINE-8,12-DIPROPANOICACID,2,17-DIETHENYL-1,10,19,22,23,24-HEXAHYDRO-3,7,13,18-TETRAMETHYL-1,19-DIOXO-, 3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid

Chemical Properties

Definition	Red coloring matter of bile. Also occurs in blood serum as decomposition product of hemoglobin.
Appearance	Light Orange to Deep Redish-Brown Crystalline Solid
Melting point	192 °C
Boiling point	641.7°C (rough estimate)
density	1.2163 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	−20°C
solubility	aqueous acid: soluble
form	powder
pka	4.62±0.10(Predicted)
color	orange
Stability:	Stable. Refrigerate.
Water Solubility	practically insoluble
Sensitive	Light Sensitive
Merck	14,1218
BRN	74376
EPA Substance Registry System	21H-Biline-8,12- dipropanoic acid, 2,17-diethenyl-1,10,19,22, 23,24-hexahydro-3,7,13,18- tetramethyl-1,19-dioxo-(635-65-4)

Safety Data

Hazard Codes	Xn
Risk Statements	62-36/37/38-20/21/22 less more
Safety Statements	22-24/25-36-26 less more
WGK Germany	2
RTECS	DU3038000
F	8
TSCA	Yes
HS Code	29339990

Raw materials And Preparation Products

Hazard Information

Chemical Properties

Light Orange to Deep Redish-Brown Crystalline Solid

Uses

Principal pigment of bile and constituent of many biliary calculi

Description

Bilirubin is a yellow breakdown product of heme catabolism, formed when heme is cleaved by heme oxygenase. This reaction produces carbon monoxide and biliverdin, which is rapidly reduced to bilirubin by biliverdin reductase. Bilirubin has key roles as a free radical scavenger with antioxidant and anti-inflammatory actions. Free and albumin-bound bilirubin can also scavenge nitric oxide (NO) and NO-related species. Unconjugated bilirubin is highly water-insoluble and must be conjugated with glucuronides to become water soluble and subsequently excreted by the liver and kidney.

General Description

Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.

Biochem/physiol Actions

Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher. This bile pigment has both antioxidant and toxic properties. It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs). It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases. Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease. It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders.

Purification Methods

An acyclic tetrapyrrole bile pigment with impurities which can be eliminated by successive Soxhlet extraction with diethyl ether and MeOH. It crystallises from CHCl3 as deep red-brown rhombs, plates or orange-red prisms from chlorobenzene (m 330o dec) and is dried to constant weight at 80o under vacuum. [Gray et al. J Chem Soc 2264, 2276 1961, Beilstein 26 III/IV 3268.]

Material Safety Data Sheet(MSDS)

Spectrum Detail

Supplier

Shandong Shenke Pharmaceutical Technology Co. , Ltd.

Telephone18763980860 15553113559

Websitehttps://www.chemicalbook.com/supplier/25332780/

Jinan Wald Chemical Co., Ltd.

Telephone0531-88773586 13210588999

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1770979/0.htm

Hubei Shiteng Chemical Technology Co. LTD

Telephone187-72749323 18971850150

Websitehttps://www.chemicalbook.com/supplier/15553011/1.htm

Xi'an Bright Herb Biotech Co., Ltd.

Telephone17391987094 18729593924

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList507772/0.htm

HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD

Telephone 19925801629

Websitehttps://www.huarongpharma.com/

Guangzhou Brand-new Changshi Pharmaceutical Biotechnology Co., Ltd

Telephone 19066311943

Website

Shanghai Boyle Chemical Co., Ltd.

Telephone 021-50182298 021-50180596

Websitehttp://www.boylechem.com

J & K SCIENTIFIC LTD.

Telephone010-82848833 400-666-7788

Websitehttp://www.jkchemical.com

Meryer (Shanghai) Chemical Technology Co., Ltd.

Telephone021-61259108 18621169109

Websitehttps://www.meryer.com/cn/index/

Alfa Aesar

Telephone400-6106006

Websitehttp://chemicals.thermofisher.cn

TCI (Shanghai) Development Co., Ltd.

Telephone021-67121386

Websitehttps://www.tcichemicals.com/CN/zh/

Beijing HwrkChemical Technology Co., Ltd

Telephone010-89508211 18501085097

Websitehttp://www.hwrkchemical.com

BeiJing Hwrk Chemicals Limted

Telephone0757-86329057 18934348241

Websitehttp://www.hwrkchemical.com/

Energy Chemical

Telephone021-021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

Shanghai Hanhong Scientific Co.,Ltd.

Telephone021-54306202 13764082696

Websitehttps://www.hanhongsci.com

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

Shandong Xiya Chemical Co., Ltd

Telephone4009903999 13355009207

Websitehttp://www.xiyashiji.com

Tianyuan Natural Product Co.,Ltd.

Telephone028-85012281 13808177790

Websitehttp://www.cdtytr.com

1of4

Send Inquriy