General procedure for the synthesis of 1-pyridin-2-yl-propan-2-one from 2-methylpyridine and acetonitrile: The compound was synthesized in 61% yield as a yellow, slightly air-sensitive oil (boiling point 67 °C, 0.5 mbar) using a method disclosed in 1962. [7] Since spectral data were not reported in the original literature, the following is added for reference: 1H NMR (300 MHz, (CD3)2SO, 298 K): δ= 2.13 (s, 3H, CH3), 3.91 (s, 2H, CH2), 7.28 (m, 2H, pyridine-H), 7.74 (m, 1H, pyridine-H), 8.47 (d, 1H pyridine-H) ppm. 13C NMR (75MHz, (CD3)2SO, 298K): δ= 30.0 (CH3), 52.3 (CH2); 121.9, 124.4, 136.6, 149.2, 155.4 (pyridine-C), 205.4 (C=O) ppm. IR (ATR): ν= 1712 (νC=O), 1652 (νC=N), 1652 (νC=O), 1652 (νC=O), 1652 (νC=O), 1652 (νC=O), 1652 (νC=N) ppm. 1652 (νC=N), 1589 (νpyridine ring), 1473, 1434, 1355, 1156, 751 cm-1.
