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Material Safety Data Sheet(MSDS)

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• Description

  1,6-Hexanediol is a waxy hygroscopic solid compound that is white in colour. The compound is a linear diol that contains two primary hydroxyl groups that are located at the terminal. 1,6-Hexanediol’s linear hydrocarbon chain enables the compound to have enhanced hardness and flexibility of polyesters. Moreover, this property is utilized in the extending chains in polyurethanes. ;

• Preparation

  1,6-Hexanediol is produced by a propriety process that is based on BASF technology. Industrially, it is prepared by the hydrogenation of adipic acid. Conversely, in the laboratory, 1,6-Hexanediol can be synthesized by the reduction of adipic acid with lithium aluminum hydride. ;

• Uses and Applications

  Polyurethanes
  1,6-Hexanediol is widely utilized in the manufacture of polyesterols such as sebacates, azelates, and adipates. These compounds are resistant to hydrolysis and have low glass transition temperature as well as high mechanical levels. 1,6-hexanediol is used as an ingredient in the preparation of a wide range of tailor-made products for numerous specialty and standard applications.
  In Acrylics
  1,6-hexanediol is utilized as an ingredient in the manufacture of the bifunctional hexanediol diacrylate which is a monomer that is normally used in conjunction with other acrylic monomers as a reactive diluent for decorative coatings and printing inks.
  In Adhesives
  Urethanes and co-terephthalates that are based on 1,6-hexanediol provide faster better tack properties and crystallization. Due to its low glass transition property, 1,6-hexanediol offers high flexibility as well as excellent adhesive properties.
  Other Uses
  1,6-hexanediol is incorporated into the production of other compounds used in polymeric thickeners, sizing agents, plasticizers for polyvinyl chloride, pesticides, and surfactants dyestuffs as a flexible building block. ;

• Safety

  1,6-hexanediol is a no-irritating to the skin. However, it can be irritative to the respiratory tract and mucous membrane. 1,6-hexanediol vapours or dust cause irritation to the eye. Severe eye exposure may cause conjunctivitis, iritis, and diffuse corneal opacity. ;

• Phase separation

  The aliphatic alcohol, 1,6-hexanediol (1,6-HD), is a widely used tool to probe liquid-liquid phase separation (LLPS) in cells. Disrupts hydrophobic interaction-induced phase separation assemblies both in vitro and in vivo. 1,6-hexanediol has been widely used to study the formation process of the membrane-less cytoplasmic/nuclear condensates/bodies, presumably formed by LLPS. 1,6-HD inhibits weak hydrophobic protein-protein or protein-RNA interactions required to form liquid droplet-like condensates/bodies (droplet melting activity). 1,6-HD was originally noticed for its ability to disrupt FG repeat interactions between nucleoporins in the nuclear pore complex and interactions between RNA-binding proteins in RNA-protein (RNP) granules in vitro. More recently, 1,6-HD was used to disrupt nuclear condensates/bodies associated with chromatin, which are thought to be formed by LLPS. Furthermore, 1,6-HD has been used to examine liquid droplet formation of chromatin or protein/chromatin complexes. However, although 1,6-HD is widely used to study protein/RNA condensates/bodies, some reports have pointed out significant limitations and caveats to its use in the context of biomolecular condensates/bodies. Indeed, the cellular effects of 1,6-HD, especially its effects on chromatin in living cells, remain unclear[1]. ;

• Quality and Analysis

  The assay of the pure product is about 98 %; impurities are various diols and -caprolactone as well as traces of water. The color number of the product determined photometrically according to the Pt/Co scale must not exceed 15 APHA. Above 70 ℃, 1,6- hexanediol tends to turn yellow. ;

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