62869-69-6

Quinuclidinol benzilate (QNB) aka BZ, is a white crystalline solid. Odorless to fruitlike.

Pharmacological agent used as muscarinic M3 antagonist for the inhaled treatment of chronic obstructive pulmonary disease (COPD).

Suspected reprotoxic hazard, drug; incapacitating agent. QNB is a glycolate anticholinergic compound that affects the CNS and peripheral nervous sys- tem (PNS) and is related to the drugs atropine, scopol- amine, and hyoscyamine. QNB is nonirritating; symptoms are delayed for several hours. QNB can be used to contami- nate water, food, and agricultural products. A highly potent drug and CNS depressant, QNB is a delayed-action inca- pacitating agent, usually dispersed as an aerosol, but it can also be used to penetrate skin when mixed with a solvent (such as DMSO), and to contaminate food and water. QNB appears to be widely used in pharmacologic research. The key to protection from QNB is prevention from entering the body with good quality aerosol filter and impermeable gloves and clothing. QMB is stable in most solvents, with a half-life of 3 to 4 weeks in moist air; it can be dispersed even with heat-producing munitions.

Eyes: After removing patient/victim from the source of exposure, immediately wash eyes with large amounts of tepid water for at least 15 minutes. Do not allow the patient/victim to rub eyes. Monitor the patient/ victim for signs of whole-body (systemic) effects; if signs appear, see the Inhalation section for treatment recom- mendations. Seek medical attention immediately. Ingestion: After removing patient/victim from the source of exposure, immediately ensure that the patient/victim has an unobstructed airway. Do not induce vomiting. See the Inhalation section for first aid recommendations. Seek medical attention immediately. Inhalation: After removing patient/victim from the source of exposure, immediately, evaluate respiratory function and pulse. Ensure that the patient/victim has an unobstructed airway. If shortness of breath occurs or breathing is difficult, administer oxygen. Assist ventilation as required. Always use a barrier or bag-valve-mask device. If breathing has ceased, provide artificial respiration. Monitor for exceptionally high body temperature. If body temperature is elevated above 102℃/ 39 ℃, initiate immediate and vigorous cooling (as for heatstroke), using 72 ℃ to 75℃/22 ℃ to 24 ℃ water and air circulation (fanning), wet cloths and air circulation, or maximum exposure to air in a shaded area with maximum air circulation. Do not use ice for skin cooling. Give fluids sparingly. Manage dryness and coating of the mouth and lips using moist swabs and small amounts of petroleum jelly. Monitor for skin abrasions caused by repetitive movements. Remove potentially harmful items, including cigarettes, matches, medications, and small items that could be accidentally ingested, from the patient/victim’s possession. Consider loose restraint of disoriented or agi- tated patient/victims. Consider separation of affected indi- viduals into small groups to minimize potential crowd control problems. Seek medical attention immediately. Skin: After removing patient/victim from the source of exposure, immediately, see the Decontamination section (above). See the Inhalation section for first aid recom- mendations. Seek medical attention immediately.

UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. Military driver shall be given full and complete information regarding shipment and conditions in case of emergency. AR 50-6 deals specifically with the shipment of chemical agents. Shipments of agent will be escorted in accordance with AR 740-32.

May form explosive mixture with air. Decomposes at about 170℃ in air under prolonged heat- ing. After 1 or 2 hours at 200℃, it is completely decom- posed. Rate of decomposition is both temperature- and purity dependent. No effect on steel or stainless steel after 3 months @ 71℃. Aluminum and anodized aluminum are mildly attacked after 3 months @ 71℃. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanga- nates, perchlorates, chlorine, bromine, fluorine, etc.); con- tact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with metals may evolve flammable hydrogen gas

Dispose of the material per IAW waste disposal methods provided below. Conduct general area monitoring with an approved monitor to con- firm that the atmospheric concentrations do not exceed the airborne exposure limit. If 10 wt.% sodium hydroxide is not available then the following decontaminants may be used instead and are listed in order of preference: Decontaminating Solution No. 2 , sodium carbonate and Supertropical Bleach Slurry (STB). Keep this chemical out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build-up of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or con- taminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your local or federal environmental protection agency for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.