627-93-0

Name	Dimethyl adipate
CAS	627-93-0
EINECS(EC#)	211-020-6
Molecular Formula	C8H14O4
MDL Number	MFCD00008469
Molecular Weight	174.19
MOL File	627-93-0.mol

Chemical Properties

Description	Dimethyl adipate (DMA) is a colourless and flammable liquid. It is soluble in alcohol and ether but sparingly soluble in water. DMA is incompatible with strong oxidising agents, and on decomposition, it emits carbon monoxide, irritating and toxic fumes and gases, and carbon dioxide. DMA reacts with acids, alkalis, and strong oxidants. DMA is synthesised by the esterification of adipic acid. DMA is part of a dibasic ester (DBE) blend used as a major ingredient in several paint strippers, and the DBE blends used in paint stripping formulations contain a major portion (about 90%) of DMA. DMA is used as a chemical intermediate (polymers, agrochemicals), cellulose resins, a speciality solvent (inks, coatings, adhesives), and an emollient and can also be utilised as a paint remover and plasticiser. less more
Appearance	colourless liquid
Melting point	8 °C (lit.)
Boiling point	109-110 °C/14 mmHg (lit.)
density	1.062 g/mL at 20 °C(lit.)
vapor pressure	0.2 mm Hg ( 20 °C)
FEMA	4472 \| DIMETHYL ADIPATE
refractive index	n20/D 1.428(lit.)
Fp	225 °F
storage temp.	Store below +30°C.
solubility	<1g/l
form	Liquid
color	Clear
Odor	at 100.00 %. mild nutty
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents, acids, bases reducing agents.
explosive limit	0.81-8.1%(V)
Odor Type	nutty
Water Solubility	Miscible with alcohols and ether. Immiscible with water.
JECFA Number	1964
Merck	14,162
BRN	1707443
InChIKey	UDSFAEKRVUSQDD-UHFFFAOYSA-N
LogP	1.4 at 22℃
CAS DataBase Reference	627-93-0(CAS DataBase Reference)
NIST Chemistry Reference	Hexanedioic acid, dimethyl ester(627-93-0)
EPA Substance Registry System	627-93-0(EPA Substance)

Safety Data

Safety Statements	S24/25:Avoid contact with skin and eyes . less more
WGK Germany	1
RTECS	AV1645000
Autoignition Temperature	680 °F
TSCA	Yes
HS Code	29171290
Precautions	During handling of dimethyl adipate, occupational workers should be careful and use self-contained breathing apparatus, rubber boots, and heavy rubber gloves and avoid prolonged period of exposures. Workers should avoid contact of dimethyl adipate with skin, eyes and nose.
Safety Profile	Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. less more
Hazardous Substances Data	627-93-0(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 8191 mg/kg LD50 dermal Rabbit > 2250 mg/kg less more

Raw materials And Preparation Products

Hazard Information

Chemical Properties

Dimethyl adipate (DMA) is a colorless and flammable liquid. It is soluble in alcohol and ether, but sparingly soluble in water. It reacts with acids, alkalis, and strong oxidants. Dimethyl adipate is synthesized by the esterifi cation of adipic acid. Dimethyl adipate is part of a dibasic ester (DBE) blend used as a major ingredient in several paint strippers; the DBE blends used in paint stripping formulations contain a major portion (about 90%) of DMA. Dimethyl adipate is used as a chemical intermediate and as a plasticizer in the production of paper and cellulose resins.

General Description

Colorless liquid.

Reactivity Profile

DIMETHYL ADIPATE(627-93-0) is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Air & Water Reactions

Flammable. Hydrolyzed by strong mineral acids and strong alkalis.

Health Hazard

Exposures to dimethyl adipate cause toxicity and adverse health effects in laboratory animals and humans. Workplace exposures to dimethyl adipate by inhalation, ingestion, or skin absorption cause harmful and irritation effects to users.

Health Hazard

May be harmful by inhalation, ingestion, or skin absorption. May cause irritation.

Uses

Dimethyl adipate is used in cosmetics (in emollients and skin conditioning).It is used as a plasticizer for cellulose-type resins and a finish remover.It is also used in agrochemicals and dye as well as a precursor for the preparation of active pharmaceutical ingredients. Further, it serves as a polymer intermediate. In addition to this, it is employed as a solvent for paint stripping and resins.

Definition

ChEBI: Dimethyl adipate is a fatty acid methyl ester.

Production Methods

Dimethyl adipate is manufactured via esterification of adipic acid and methanol in the presence of an acid catalyst.

Flammability and Explosibility

Nonflammable

Synthesis

Dimethyl adipate was synthesized by immobilized Candida antarctica lipase B-catalyzed esterification of adipic acid and methanol.
Synthesis of Diethyl Adipate

According to the general procedure described above, Dimethyl adipate has been synthesized from adipic acid (730mg, 5 mmol) and methanol (10 ml). Yield: 9%.
1H NMR (400.1 MHz, CDCl3): δ = 3.56 (6H, s, H1-H10), 2.23 (4H, m, H4-H7), 1.56 (4H, m, H5-H6).
13C NMR (100.5 MHz, CDCl3): δ = 173.4 (C3-C8), 51.2 (C1-C10), 33.4 (C4-C7), 24.1 (C5-C6)
https://pubmed.ncbi.nlm.nih.gov/20632329/

Carcinogenicity

In a chronic inhalation toxicity study of dimethyl adipate, groups of male and female rats were exposed to 400 mg/m³ of dimethyl adipate over a 90-day period. Focal respiratory metaplasia of the olfactory epithelium was found. These nonneoplastic lesions were minimal to mild in severity .

Material Safety Data Sheet(MSDS)

Spectrum Detail

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