ChemicalBook CAS DataBase List 6138-79-0

6138-79-0

Name	Triprolidine hydrochloride
CAS	6138-79-0
EINECS(EC#)	627-740-2
Molecular Formula	C19H23ClN2
MDL Number	MFCD00150574
Molecular Weight	314.85
MOL File	6138-79-0.mol

Synonyms

TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE pyridine,2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-,monohydrochloride,monohyd Pyridine,2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]-,monohydrochloride,monohydrate,stereoisomer rate,stereoisomer triprolidinesigmareferencestandard Tripolidine Hydrochloride TRIPROLIDINE HCL USP TRIPROLIDINE HCL MONOHYDRATE trans-TriprolidineHCl Pyridine, 2-(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl-, monohydrochloride, monohydrate TRIPROLIDINEHYDROCHLORIDE,USP 2-[(1E)-1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine hydrochloride monohydrate trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene hydrochloride monohydrate trans-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride monohydrate (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride 2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine monohydrochloride Triprolidine hydrochloride 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-prop-1-enyl]pyridine (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride 2-[(E)-1-(4-Methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrate hydrochloride

Chemical Properties

Appearance	White crystalline powder
Melting point	115-120°C
storage temp.	2-8°C
solubility	alcohol: soluble1 in 1.5 of solvent
form	neat
color	White to Off-White
Stability:	Stable, but discolours in light. Incompatible with strong oxidizing agents.
Water Solubility	>=10 g/100 mL at 20 ºC
Usage	Triprolidine hydrochloride monohydrate is used as bulk pharmaceutical (antihistaminic). Product Data Sheet
Merck	13,9817
InChI	InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
InChIKey	WYUYEJNGHIOFOC-NWBUNABESA-N
SMILES	C(=C/CN1CCCC1)(\C1=NC=CC=C1)/C1C=CC(C)=CC=1.Cl
LogP	4.223 (est)
CAS DataBase Reference	6138-79-0(CAS DataBase Reference)
EPA Substance Registry System	6138-79-0(EPA Substance)

Safety Data

Hazard Codes	Xn
Risk Statements	R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . less more
WGK Germany	3
RTECS	UT7658000
HS Code	2933399090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Hazard Information

General Description

Odorless white crystalline powder. Bitter taste.

Reactivity Profile

TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE(6138-79-0) discolors on exposure to light.

Air & Water Reactions

Water soluble.

Health Hazard

SYMPTOMS: Symptoms of exposure to this compound may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea.

Fire Hazard

Flash point data for this chemical are not available; however, TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE is probably combustible.

Chemical Properties

TRIPROLIDINE HYDROCHLORIDE is a white, crystalline powder.

Uses

anticholinergic (opthalmic)

Uses

TRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet

Definition

TRIPROLIDINE HYDROCHLORIDE is a hydrate that is the monohydrate form of triprolidine hydrochloride. A sedating antihistamine, it is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.

Brand name

Actidil (GlaxoSmithKline); Myidyl (USl).

Biological Activity

Potent H 1 receptor antagonist.

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information

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