Synthesis
4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate (200 mg) was used as starting material and dissolved in methanol (2 ml). Subsequently, aqueous ammonia solution (7N, 1 ml) was added to the reaction system. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure to afford the target product 4-((3-chloro-2-fluorophenyl)amino)-7-methoxy-6-ol (white solid, 176 mg, quantitative yield).
References
[1] Patent: CN108329276, 2018, A. Location in patent: Paragraph 0075; 0076
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 18, p. 4455 - 4459
[3] Patent: WO2005/28469, 2005, A1. Location in patent: Page/Page column 59
[4] Patent: WO2005/28470, 2005, A1. Location in patent: Page/Page column 54
[5] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 18, p. 4908 - 4912
