6011-12-7

Ambazone,Generic

Ambazone monohydrate is an orally active membrane active antitumor agent. Ambazone monohydrate also shows antibacterial and weak antiviral activities[1].

To a solution of 22.7 g of quinone monoguanylhydrazone nitrate in 250 ml water is added dropwise hot aqueous solution of 9.1 g thiosemicarbazide, then is added slowly a solution of 5 ml concentrated nitric acid in 10 ml of water. The mixture is stirred at 60°C for 1 hour. The product is dissolved in 1-1.2 L of water at 100°C. The solution is filtered and added to an aqueous ammonium solution. Blue residue of p-benzoquinone amidinohydrazone thiosemicarbazone is filtered and dried, melting point 188°C (decomp.).

Antiseptic

[1] G L?ber, et al. Ambazone as a membrane active antitumor drug. Biophys Chem. 1990 Apr;35(2-3):287-300. DOI:10.1016/0301-4622(90)80016-z