Mezlocillin is a β-lactam antibiotic and derivative of ampicillin (Item No.
14417).
1,2 It is active against
B. fragilis,
E. lentum,
P. morbillorum, and
F. nucleatum (MICs = 8, 4, 2, and 4 μg/ml, respectively).
2 Mezlocillin (32 μg/ml) is also active against 10 strains of
S. faecalis.
1 In vivo, mezlocillin (240 mg/kg) increases survival and reduces bacteremia in a rabbit model of
S. faecalis endocarditis. It completely eliminates lung
P. morbillorum,
E. lentum, and
F. nucelatum, but not
B. fragilis, in a rabbit model of pulmonary
P. morbillorum,
E. lentum,
F. nucelatum, and
B. fragilis infection when administered at a dose of 300 mg/kg.
2 Formulations containing mezlocillin have been used in the treatment of various bacterial infections.
