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Salsolinol is derived from the neurotransmitter dopamine and acetaldehyde. Interest in this molecule comes from studies suggesting that it might be involved in alcohol addiction, as acetaldehyde is both a well recognized substrate for the Pictet-Spengler reaction and the primary metabolite of ethanol in the liver. It has further been suggested that acetaldehyde formed as a result of alcohol consumption might induce central changes in the metabolism of dopamine.

ChEBI: 1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide is a hydrobromide. It contains a 1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol.

Salsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) is present in various edibles. It is available as?R?and?S?enantiomers. R-salsolinol in predominantly found in the brain tissue of humans.

Salsolinol, a neurotoxin, can serve as a prolactin-releasing factor and an etiological factor in the tuberoinfundibular pathway and in Parkinson′s disease (PD), respectively. It can also act as a modulator of catecholaminergic neurotransmission in the nigrostriatal pathway. In central nervous system, salsolinol can change the role of dopaminergic neurons and dopamine metabolism.