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8-Br-ADPR (8-Bromoadenosine-5'-O-diphosphoribose), an analogue of Adenosine 5′-diphosphoribose (HY-100973), is a TRPM2 modulator. 8-Br-ADPR is a human TRPM2 (hsTRPM2) inhibitor and a Nematostella vectensis (nvTRPM2) partial agonist (EC50 of 31.9 μM). 8-Br-ADPR regulates calcium release from the endoplasmic reticulum and sarcoplasmic reticulum[1].

[1] Tóth B, et al. Selective profiling of N- and C-terminal nucleotide-binding sites in a TRPM2 channel. J Gen Physiol. 2020 May 4;152(5):e201912533. DOI:10.1085/jgp.201912533