The acute LD50 values for the sodium salt of Ambruticin in mice were: intravenous 315 mg/kg, oral > 1000 mg/kg[1].
Ambruticin is rapidly absorbed by the oral route in mice. Ambruticin (75 mg/kg, gavage) produces a peak serum level of 46 μg/mL with a serum half-life of 3.1 h[2].
Ambruticin (40 mg/kg, oral, twice daily for a total of 10 days) shows protective activity in Guinea pigs infected with a severe T. mentagrophytes challenge[2].
Ambruticin shows protective activity in mice acutely infected with a severe C. albicans challenge[2].
| Animal Model: | Guinea pigs (infected with a strain of T. mentagrophytes)[2] |
| Dosage: | 40 mg/kg |
| Administration: | Oral, starting on day 3 postinfection, twice daily for a total of 10 days |
| Result: | On postinfection day 15, the guinea pig mean lesion score was approximately 1.3; by postinfection day 27, all the lesions were essentially healed. |
