58857-02-6

The acute LD₅₀ values for the sodium salt of Ambruticin in mice were: intravenous 315 mg/kg, oral > 1000 mg/kg^[1].
Ambruticin is rapidly absorbed by the oral route in mice. Ambruticin (75 mg/kg, gavage) produces a peak serum level of 46 μg/mL with a serum half-life of 3.1 h^[2].
Ambruticin (40 mg/kg, oral, twice daily for a total of 10 days) shows protective activity in Guinea pigs infected with a severe T. mentagrophytes challenge^[2].
Ambruticin shows protective activity in mice acutely infected with a severe C. albicans challenge^[2].