Synthesis
General procedure for the synthesis of 2,4-dimethylbromobenzene from m-xylene: N-bromosuccinimide (NBS, 1.0 mmol) and Catalyst 1 (gold loading of 0.1 or 1 mol% of the substrate) were accurately weighed and added to a 10 mL sealed reaction vessel, followed by 1,2-dichloroethane (DCE, 2 mL) and m-xylene (1.0 mmol). The reaction mixture was stirred at a set temperature for a specified time. After completion of the reaction, the catalyst was separated using a magnet and the reaction solution was concentrated under reduced pressure and purified by column chromatography.
References
[1] Russian Journal of Applied Chemistry, 2006, vol. 79, # 6, p. 949 - 956
[2] Canadian Journal of Chemistry, 2009, vol. 87, # 2, p. 440 - 447
[3] Tetrahedron Letters, 2013, vol. 54, # 9, p. 1063 - 1066
[4] Russian Journal of Organic Chemistry, 2005, vol. 41, # 11, p. 1631 - 1636
[5] Catalysis Letters, 2012, vol. 142, # 3, p. 378 - 383
