Description
(?)-Apomorphine is a non-selective dopamine receptor agonist that exhibits pK
i values of 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D
1, D
2L, D
3, D
4, and D
5 receptors, respectively.
1,2 It produces biphasic effects on locomotor activity and displays anti-
parkinsonian and neuroprotective actions.
1,3,4
References
1. Millan, M.J., Maiofiss, L., Cussac, D., et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes J. Pharmacol. Exp. Ther. 303(2),791-804(2002).
2. Seeman, P., Grigoriadis, D.E., and Niznik, H.B. Selectivity of agonists and antagonists at D2 dopamine receptors compared to D1 and S2 receptors Drug Dev. Res. 9,63-69(1986).
3. Newman-Tancredi, A., Cussac, D., Audinot, V., et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D2-like receptor and α1/α2-adrenoceptor J. Pharmacol. Exp. Ther. 303(2),805-814(2002).
4. Schechter, M.D., Rosecrans, J.A., and Glennon, R.A. Comparison of behavioral effects of cathinone, amphetamine and apomorphine Pharmacol. Biochem. Behav. 20(2),181-184(1984).
