57103-51-2

Nauclefine (5 mg/kg, intratumorally, once per day for 22 days) significantly reduces the overall growth of HeLa-luc cell tumors in female nude mice (Balb/c-nu) infected with HeLa cells, especially after treatment 6 Days later, the tumor volume is significantly reduced without causing any decrease in the body weight of the mice. Its inhibition of tumor growth depends on the expression of PDE3A and SLFN12^[1].